Precursor B Lymphoblastic Leukemia With Surface Light Chain Immunoglobulin Restriction
نویسندگان
چکیده
منابع مشابه
Submicroscopic Deletions of Immunoglobulin Heavy Chain Gene (IGH) in Precursor B Lymphoblastic Leukemia with IGH Rearrangements
Translocations leading to fusions between the immunoglobulin heavy chain gene (IGH) and various partner genes have been reported in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, submicroscopic deletions within IGH in B-ALL have not been rigorously assessed. In this study, we investigated characteristics of IGH submicroscopic deletions, by FISH, in B-ALL with IGH rearrangements...
متن کاملMassive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia.
The ability to distinguish clonal B-cell populations based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important tool for diagnosing B-cell neoplasms and monitoring treatment response. Leukemic precursor B cells may continue to undergo recombination of the IgH gene after malignant transformation; however, the magnitude of evolution at the IgH locus is curren...
متن کاملLYMPHOID NEOPLASIA Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
The ability to distinguish clonal B-cell populations based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important tool for diagnosing B-cell neoplasms and monitoring treatment response. Leukemic precursor B cells may continue to undergo recombination of the IgH gene after malignant transformation; however, the magnitude of evolution at the IgH locus is curren...
متن کاملMYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia
MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B...
متن کاملImmunoglobulin light chain gene rearrangements in precursor-B-acute lymphoblastic leukemia: characteristics and applicability for the detection of minimal residual disease
Precursor B-acute lymphoblastic leukemias (ALL) can be considered as malignant counterparts of normal precursor B cells arrested in a particular stage of development. So far, most studies on immunoglobulin (Ig) light chain gene rearrangements have focused on IGK-Kde rearrangements, and studies on Vκ-Jκ and Vλ-Jλ rearrangements mainly used Southern blot analysis and/or included only small series...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2004
ISSN: 0002-9173,1943-7722
DOI: 10.1309/wtxcq5nracvxtyby